A New Indole Derivative, LWX-473, Overcomes Glucocorticoid Resistance in Jurkat Cells by Activating Mediators of Apoptosis

Background: Glucocorticoids (GCs) are commonly used as the primary chemotherapy for lymphoid malignancies, including acute lymphoblastic leukemia (ALL).However, the development of GC resistance limits their prolonged use.Methods: In this study, we investigated the potential of a newly synthesized indole derivative called LWX-473, in combination wit

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Isolated infundibular pulmonary stenosis

A case of isolated infundibular pulmonary stenosis is reported and literature is reviewed.Infundibular pulmonary stenosis is usually VAGINAL DILATORS a part of tetralogy of Fallot or is associated with ventricular septal defect.Isolated infundibular pulmonary stenosis is rare.Patients may be asymptomatic in spite of significant stenosis.Dyspnea, ch

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